血清S-ChE、PAB、Apo A1及APACHEⅡ評分對重癥肺炎預后的評估

以下是大綱或介紹,如需要完整的資料請購買下載. 本資料已審核過,內容保密,格式標準,質量保證.  
1.無需注冊登錄,購買下載后即可獲取該完整的資料.
2.購買后本站提供下載鏈接或聯系客服發送資料.
資料介紹

血清S-ChE、PAB、Apo A1及APACHEⅡ評分對重癥肺炎預后的評估(論文4800字)
[摘要]目的 探討血清膽堿酯酶(S-ChE)、前白蛋白(PAB)、載脂蛋白A1(Apo A1)及急性生理學與慢性健康狀況系統Ⅱ(APACHEⅡ)評分對重癥肺炎預后的評估作用方法 選擇2015年3月至2017年3月我院接診的70例重癥肺炎患者作為本研究對象,根據APACHEⅡ評分<20分為A組,APACHEⅡ評分≥20分為B組,比較兩組多器官功能障礙綜合征(MODS)發生率及死亡率;根據是否發生MODS分為MODS組和非MODS組,根據28d后轉歸情況分為死亡組和存活組,比較組間血清S-ChE、PAB、Apo A1及APACHEⅡ評分的差異。結果 A組MODS發生率、死亡率均明顯低于B組[17.24%(5/29)vs43.90%(18/41),10.34%(3/29)vs41.46%(17/41)](P<0.05);MODS組血清S-ChE、PAB、Apo A1明顯低于非MODS組[(2.84±0.33)kU/L vs(4.53±0.40)kU/L,(118.45±15.20)mg/L vs(204.61±17.92)mg/L,(0.60±0.11)g/L vs(1.15±0.21)g/L],APACHEⅡ評分明顯高于非MODS組[(26.91±2.74)分vs(19.58±2.04)分],比較均具有顯著差異(P<0.05);死亡組血清S-ChE、PAB、Apo A1明顯低于存活組[(2.75±0.31)kU/L vs(4.46±0.29)kU/L,(109.86±15.73)mg/L vs(184.51±16.85)mg/L,(0.59±0.12)g/L vs(1.12±0.18)g/L],APACHEⅡ評分明顯高于存活組[(28.95±2.40)分vs(18.58±1.97)分],比較均具有顯著差異(P<0.05);Logistic回歸分析結果中顯示,S-ChE、PAB、Apo A1、APACHEⅡ評分均是影響重癥肺炎預后的獨立危險因素(OR=0.082、0.137、0.096、1.798,P均<0.05)。結論 血清S-ChE、PAB、Apo A1及APACHEⅡ評分對重癥肺炎預后均具有良好的評估價值。
【關鍵詞】重癥肺炎;膽堿酯酶;前白蛋白;載脂蛋白A1;急性生理學與慢性健康狀況系統Ⅱ評分
Evaluation of prognosis of severe pneumonia by serum S-ChE, PAB, Apo A1 and APACHE II score
[Abstract] Objective To study the evaluation of prognosis of severe pneumonia by serum cholinesterase(S-ChE), prealbumin(PAB), apolipoprotein A1(Apo A1) and Acute physiology and chronic health scoring system II (APACHE II) score. Methods 70 patients of severe pneumonia who received therapy from March 2015 to March 2017 in our hospital were selected as research objects. According to the APACHE score<20 divided into A group, APACHE score≥20 were divided into B group, the incidence of multiple organ dysfunction syndrome (MODS) and mortality were compared between the two groups; depending on whether MODS occurred divided into MODS and non MODS groups, according to the prognosis after 28d, the patients were divided into the death group and the survival group, the differences of serum S-ChE, PAB, Apo A1 and APACHE II scores between the two groups were compared. Results The incidence of the MODS and mortality in Agroup were significantly lower than those in group B[17.24%(5/29)vs43.90%(18/41), 10.34%(3/29)vs41.46%(17/41)] (P<0.05); the serum S-ChE, PAB, Apo A1 in MODS group were significantly lower than those in non MODS group[(2.84±0.33)kU/L vs(4.53±0.40)kU/L, (118.45±15.20)mg/L vs(204.61±17.92)mg/L, (0.60±0.11)g/L vs(1.15±0.21)g/L], the APACHE score was higher than those in non MODS group[(26.91±2.74)score vs(19.58±2.04)score], the difference was statistically significant(P<0.05); the serum S-ChE, PAB, Apo A1 in death group were significantly lower than those in survival group[(2.75±0.31)kU/L vs(4.46±0.29)kU/L, (109.86±15.73)mg/L vs(184.51±16.85)mg/L, (0.59±0.12)g/L vs(1.12±0.18)g/L],the APACHE score was higher than those in survival group[(28.95±2.40) score vs(18.58±1.97) score], the difference was statistically significant(P<0.05); the Logistic regression analysis showed that the scores of S-ChE, PAB, Apo, A1 and APACHE II were independent risk factors for the prognosis of severe pneumonia(OR=0.082, 0.137, 0.096, 1.798, Pall<0.05). Conclusion The serum S-ChE, PAB, Apo A1 and APACHE II scores have a good evaluation value in the prognosis of severe pneumonia.
Key words: Severe pneumonia; Cholinesterase; Prealbumin; Apolipoprotein A1; Acute physiology and chronic health scoring system II score

快乐8玩法